An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk.

ABSTRACT: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modeled outcomes for 1217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals. We discovered 49 and 1 associations between a disease and ABO and RhD blood groups, respectively, after adjustment for multiple testing. We identified new associations such as a decreased risk of kidney stones and blood group B as compared to blood group O. We also expanded previous knowledge on other associations such as pregnancy-induced hyperte

SUBMITTER: Dahlen T 

PROVIDER: S-EPMC8143790 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature