Comparative characterization of PCDH19 missense and truncating variants in PCDH19-related epilepsy.

ABSTRACT: Missense and truncating variants in protocadherin 19 (PCDH19) cause PCDH19-related epilepsy. In this study, we aimed to investigate variations in distributional characteristics and the clinical implications of variant type in PCDH19-related epilepsy. We comprehensively collected PCDH19 missense and truncating variants from the literature and by sequencing six exons and intron-exon boundaries of PCDH19 in our cohort. We investigated the distribution of each type of variant using the cumulative distribution function and tested for associations between variant types and phenotypes. The distribution of missense variants in patients was clearly different from that of healthy individuals and was uniform throughout the extracellular cadherin (EC) domain, which consisted of six highly conserved do

SUBMITTER: Shibata M 

PROVIDER: S-EPMC8144015 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature