Metabolic reprogramming of inner ear cell line HEI-OC1 after dexamethasone application.

ABSTRACT:

Introduction

One approach to dampen the inflammatory reactions resulting from implantation surgery of cochlear implant hearing aids is to embed dexamethasone into the matrix of the electrode carrier. Possible side effects for sensory cells in the inner ear on the metabolomics have not yet been evaluated.

Objective

We examined changes in the metabolome of the HEI-OC1 cell line after dexamethasone incubation as a cell model of sensory cells of the inner ear.

Results and conclusion

Untargeted GC-MS-profiling of metabolic alterations after dexamethasone treatment showed that dexamethasone had antithetical effects on the metabolic signature of the cells depending on growth conditions. The differentiated state of HEI-OC1 cells is better suited for elucidating metabolic chan

SUBMITTER: Kather M 

PROVIDER: S-EPMC8144088 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature