Gut-liver axis modulation of Panax notoginseng saponins in nonalcoholic fatty liver disease.

ABSTRACT:

Background and aims

Nonalcoholic fatty liver disease (NAFLD) is an obesity-related comorbidity, and it is characterized as a spectrum of liver abnormalities, including inflammation, steatosis, and fibrosis. The gut-liver axis is implicated in the pathogenesis and development of NAFLD. A promising drug agent targeting the gut-liver axis is expected to reverse NAFLD.

Methods

We utilized high-fat diet (HFD)-induced obese mice and obesity-prone Lep^ob mice to examine the gut-liver regulation of the natural medicine Panax Notoginseng Saponins (PNS) on NAFLD.

Results

PNS exhibited potent anti-lipogenesis and anti-fibrotic effects in NAFLD mice, that was associated with the TLR4-induced inflammatory signalling pathway in liver. More strikingly, PNS treatment caused

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8144126 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature