Assessment of optogenetically-driven strategies for prosthetic restoration of cortical vision in large-scale neural simulation of V1.

ABSTRACT: The neural encoding of visual features in primary visual cortex (V1) is well understood, with strong correlates to low-level perception, making V1 a strong candidate for vision restoration through neuroprosthetics. However, the functional relevance of neural dynamics evoked through external stimulation directly imposed at the cortical level is poorly understood. Furthermore, protocols for designing cortical stimulation patterns that would induce a naturalistic perception of the encoded stimuli have not yet been established. Here, we demonstrate a proof of concept by solving these issues through a computational model, combining (1) a large-scale spiking neural network model of cat V1 and (2) a virtual prosthetic system transcoding the visual input into tailored light-stimulation patterns wh

SUBMITTER: Antolik J 

PROVIDER: S-EPMC8144184 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature