An early look at selective RET inhibitor resistance: new challenges and opportunities.
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ABSTRACT:
SUBMITTER: Lin JJ
PROVIDER: S-EPMC8144197 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
An early look at selective RET inhibitor resistance: new challenges and opportunities.
Lin Jessica J JJ Gainor Justin F JF
British journal of cancer 20210323 11
Two RET inhibitors, selpercatinib and pralsetinib, recently received approval for the treatment of advanced RET fusion-positive lung cancer. Acquired resistance to these inhibitors will be a major challenge. We have shown that resistance can emerge due to recurrent RET kinase domain mutations and, in most cases, due to RET-independent mechanisms. ...[more]
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