Beta-agonist drugs modulate the proliferation and differentiation of skeletal muscle cells in vitro.

ABSTRACT: Essentially employed for the treatment of airway obstructions in humans, β-agonists are also known to have an anabolic effect in animals' skeletal muscle. In vivo and in vitro studies have attested the increase in animal body mass and the hypertrophy of muscle cells following the administration of specific β-agonists. However, the contribution of β-agonists to C2C12 myoblasts growth remains obscure. We therefore aimed to investigate the impact of β1-and β2-agonist drugs on the proliferation and differentiation of skeletal muscle cells. Direct observations and cytotoxicity assay showed that clenbuterol, salbutamol, cimaterol and ractopamine enhanced muscle cell growth and viability during the proliferation stage. Structural examinations coupled to Western blot analysis indicat

SUBMITTER: Flavie Ouali BE 

PROVIDER: S-EPMC8144337 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature