Ontology highlight
ABSTRACT:
SUBMITTER: Wojnarowicz PM
PROVIDER: S-EPMC8144414 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Wojnarowicz Paulina M PM Escolano Marta Garcia MG Huang Yun-Han YH Desai Bina B Chin Yvette Y Shah Riddhi R Xu Sijia S Yadav Saurabh S Yaklichkin Sergey S Ouerfelli Ouathek O Soni Rajesh Kumar RK Philip John J Montrose David C DC Healey John H JH Rajasekhar Vinagolu K VK Garland William A WA Ratiu Jeremy J Zhuang Yuan Y Norton Larry L Rosen Neal N Hendrickson Ronald C RC Zhou Xi Kathy XK Iavarone Antonio A Massague Joan J Dannenberg Andrew J AJ Lasorella Anna A Benezra Robert R
NPJ breast cancer 20210524 1
ID proteins are helix-loop-helix (HLH) transcriptional regulators frequently overexpressed in cancer. ID proteins inhibit basic-HLH transcription factors often blocking differentiation and sustaining proliferation. A small-molecule, AGX51, targets ID proteins for degradation and impairs ocular neovascularization in mouse models. Here we show that AGX51 treatment of cancer cell lines impairs cell growth and viability that results from an increase in reactive oxygen species (ROS) production upon I ...[more]