Differential Metabolites in Chinese Autistic Children: A Multi-Center Study Based on Urinary ¹H-NMR Metabolomics Analysis.

ABSTRACT: Background: Autism spectrum disorder (ASD) is a group of early-onset neurodevelopmental disorders. However, there is no valuable biomarker for the early diagnosis of ASD. Our large-scale and multi-center study aims to identify metabolic variations between ASD and healthy children and to investigate differential metabolites and associated pathogenic mechanisms. Methods: One hundred and seventeen autistic children and 119 healthy children were recruited from research centers of 7 cities. Urine samples were assayed by ¹H-NMR metabolomics analysis to detect metabolic variations. Multivariate statistical analysis, including principal component analysis (PCA), and orthogonal projection to latent structure discriminant analysis (OPLS-DA), as well as univariate analysis we

SUBMITTER: Ma Y 

PROVIDER: S-EPMC8144639 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature