Social Experience Regulates Endocannabinoids Modulation of Zebrafish Motor Behaviors.

ABSTRACT: Social status-dependent modulation of neural circuits has been investigated extensively in vertebrate and invertebrate systems. However, the effects of social status on neuromodulatory systems that drive motor activity are poorly understood. Zebrafish form a stable social relationship that consists of socially dominant and subordinate animals. The locomotor behavior patterns differ according to their social ranks. The sensitivity of the Mauthner startle escape response in subordinates increases compared to dominants while dominants increase their swimming frequency compared to subordinates. Here, we investigated the role of the endocannabinoid system (ECS) in mediating these differences in motor activities. We show that brain gene expression of key ECS protein pathways are socially regulat

SUBMITTER: Orr SA 

PROVIDER: S-EPMC8144649 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature