Individualized Mechanical power-based ventilation strategy for acute respiratory failure formalized by finite mixture modeling and dynamic treatment regimen.

ABSTRACT:

Background

Mechanical ventilation (MV) is the key to the successful treatment of acute respiratory failure (ARF) in the intensive care unit (ICU). The study aims to formalize the concept of individualized MV strategy with finite mixture modeling (FMM) and dynamic treatment regime (DTR).

Methods

ARF patients requiring MV for over 48 h from 2008 to 2019 were included. FMM was conducted to identify classes of ARF. Static and dynamic mechanical power (MP_static and MP_dynamic) and relevant clinical variables were calculated/collected from hours 0 to 48 at an interval of 8 h. ΔMP was calculated as the difference between actual and optimal MP.

Findings

A total of 8768 patients were included for analysis with a mortality rate of 27%. FFM identified three classes of ARF, name

SUBMITTER: Hong Y 

PROVIDER: S-EPMC8144670 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature