Placenta-Derived Exosomes as a Modulator in Maternal Immune Tolerance During Pregnancy.

ABSTRACT: Exosomes are a subset of extracellular vesicles with an average diameter of ~100nm. Exosomes are released by all cells through an endosome-dependent pathway and carry nucleic acids, proteins, lipids, cytokines and metabolites, mirroring the state of the originating cells. The function of exosomes has been implicated in various reproduction processes, such as embryo development, implantation, decidualization and placentation. Placenta-derived exosomes (pEXO) can be detected in the maternal blood as early as 6 weeks after conception and their levels increase with gestational age. Importantly, alternations in the molecular signatures of pEXO are observed in pregnancy-related complications. Thus, these differentially expressed molecules could be the potential biomarkers for diagnosis of the pr

SUBMITTER: Bai K 

PROVIDER: S-EPMC8144714 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature