A Novel Ferroptosis Related Gene Signature for Prognosis Prediction in Patients With Colon Cancer.

ABSTRACT:

Purpose

Colon cancer (CC) is a serious disease burden. The prognosis of patients with CC is different, so looking for effective biomarkers to predict prognosis is vitally important. Ferroptosis is a promising therapeutic and diagnosis strategy in CC. However, the role of ferroptosis in prognosis of CC has not been studied. The aim of the study is to build a prognosis model related ferroptosis, and provide clues for further therapy of CC.

Methods

The RNA-seq data were from TCGA (training group) and GEO (testing group). The R language and Perl language were used to process and analyze data. LASSO regression analysis was used to build the prognosis model. ssGSEA was used to compare the immune status between two groups. Immunohistochemistry was used to detect expression of AKR1C

SUBMITTER: Nie J 

PROVIDER: S-EPMC8144717 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature