Ontology highlight
ABSTRACT:
SUBMITTER: Zheng C
PROVIDER: S-EPMC8144839 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Zheng Chenxi C Sui Bingdong B Zhang Xiao X Hu Jiachen J Chen Ji J Liu Jin J Wu Di D Ye Qingyuan Q Xiang Lei L Qiu Xinyu X Liu Siying S Deng Zhihong Z Zhou Jun J Liu Shiyu S Shi Songtao S Jin Yan Y
Journal of extracellular vesicles 20210524 7
Apoptosis is a naturally occurring process generating plenty of apoptotic vesicles (apoVs), but the feature, fate and function of apoVs remain largely unknown. Notably, as an appealing source for cell therapy, mesenchymal stem cells (MSCs) undergo necessary apoptosis and release apoVs during therapeutic application. In this study, we characterized and used MSC-derived apoVs to treat type 2 diabetes (T2D) mice, and we found that apoVs were efferocytosed by macrophages and functionally modulated l ...[more]