Integrative omics provide biological and clinical insights into acute respiratory distress syndrome.

ABSTRACT:

Purpose

Acute respiratory distress syndrome (ARDS) is accompanied by a dysfunctional immune-inflammatory response following lung injury, including during coronavirus disease 2019 (COVID-19). Limited causal biomarkers exist for ARDS development. We sought to identify novel genetic susceptibility targets for ARDS to focus further investigation on their biological mechanism and therapeutic potential.

Methods

Meta-analyses of ARDS genome-wide association studies were performed with 1250 cases and 1583 controls in Europeans, and 387 cases and 387 controls in African Americans. The functionality of novel loci was determined in silico using multiple omics approaches. The causality of 114 factors potentially involved in ARDS development was assessed using Mendelian Randomization ana

SUBMITTER: Du M 

PROVIDER: S-EPMC8144871 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature