Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures.

ABSTRACT:

Importance

Antiseizure medication (ASM) treatment duration for acute symptomatic neonatal seizures is variable. A randomized clinical trial of phenobarbital compared with placebo after resolution of acute symptomatic seizures closed early owing to low enrollment.

Objective

To assess whether ASM discontinuation after resolution of acute symptomatic neonatal seizures and before hospital discharge is associated with functional neurodevelopment or risk of epilepsy at age 24 months.

Design, setting, and participants

This comparative effectiveness study included 303 neonates with acute symptomatic seizures (282 with follow-up data and 270 with the primary outcome measure) from 9 US Neonatal Seizure Registry centers, born from July 2015 to March 2018. The centers all had lev

SUBMITTER: Glass HC 

PROVIDER: S-EPMC8145161 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature