Alzheimer's disease drug development pipeline: 2021.

ABSTRACT:

Introduction

The number of individuals worldwide with Alzheimer's disease (AD) is growing at a rapid rate. New treatments are urgently needed. We review the current pipeline of drugs in clinical trials for the treatment of AD.

Methods

We interrogated ClinicalTrials.gov, the federal registry of clinical trials to identify drugs in trials.

Results

There are 126 agents in 152 trials assessing new therapies for AD: 28 treatments in Phase 3 trials, 74 in Phase 2, and 24 in Phase 1. The majority of drugs in trials (82.5%) target the underlying biology of AD with the intent of disease modification; 10.3% are putative cognitive enhancing agents; and 7.1% are drugs being developed to reduce neuropsychiatric symptoms.

Discussion

This pipeline analysis shows that target b

SUBMITTER: Cummings J 

PROVIDER: S-EPMC8145448 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature