1,3,4-Thiadiazoles Effectively Inhibit Proliferation of Toxoplasma gondii.

ABSTRACT: Congenital and acquired toxoplasmosis caused by the food- and water-born parasite Toxoplasma gondii (T. gondii) is one of the most prevalent zoonotic infection of global importance. T. gondii is an obligate intracellular parasite with limited capacity for extracellular survival, thus a successful, efficient and robust host cell invasion process is crucial for its survival, proliferation and transmission. In this study, we screened a series of novel 1,3,4-thiadiazole-2-halophenylamines functionalized at the C5 position with the imidazole ring (1b-12b) for their effects on T. gondii host cell invasion and proliferation. To achieve this goal, these compounds were initially subjected to in vitro assays to assess their cytotoxicity on human fibroblasts and then antiparasitic efficacy. Results s

SUBMITTER: Weglinska L 

PROVIDER: S-EPMC8145641 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature