RNA-Binding Protein HuD as a Versatile Factor in Neuronal and Non-Neuronal Systems.

ABSTRACT: HuD (also known as ELAVL4) is an RNA-binding protein belonging to the human antigen (Hu) family that regulates stability, translation, splicing, and adenylation of target mRNAs. Unlike ubiquitously distributed HuR, HuD is only expressed in certain types of tissues, mainly in neuronal systems. Numerous studies have shown that HuD plays essential roles in neuronal development, differentiation, neurogenesis, dendritic maturation, neural plasticity, and synaptic transmission by regulating the metabolism of target mRNAs. However, growing evidence suggests that HuD also functions as a pivotal regulator of gene expression in non-neuronal systems and its malfunction is implicated in disease pathogenesis. Comprehensive knowledge of HuD expression, abundance, molecular targets, and regulatory mechan

SUBMITTER: Jung M 

PROVIDER: S-EPMC8145660 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature