Impact of Immune Priming, Vaccination, and Infection on Influenza A(H3N2) Antibody Landscapes in Children.

ABSTRACT:

Background

Preexisting antibodies to influenza, shaped by early infection and subsequent exposures, may impact responses to influenza vaccination.

Methods

We enrolled 72 children (aged 7-17 years) in 2015-2016; all received inactivated influenza vaccines. Forty-one were also vaccinated in 2014-2015, with 12 becoming infected with A(H3N2) in 2014-2015. Thirty-one children did not have documented influenza exposures in the prior 5 seasons. Sera were collected pre- and postvaccination in both seasons. We constructed antibody landscapes using hemagglutination inhibition antibody titers against 16 A(H3N2) viruses representative of major antigenic clusters that circulated between 1968 and 2015.

Results

The breadth of the antibody landscapes increased with age. Vaccine-induc

SUBMITTER: Hinojosa M 

PROVIDER: S-EPMC8145779 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature