How bulky ligands control the chemoselectivity of Pd-catalyzed N-arylation of ammonia.

ABSTRACT: Steric bulk has been recognized as a central design principle for supporting ligands in the widely utilized Buchwald-Hartwig amination. In a recent example, it was shown that a Pd-catalyst carrying a phosphine ligand can successfully aminate aryl halides using ammonia as the nitrogen source. Interestingly, the chemoselectivity of this reaction was found to depend on the steric demand of the phosphine ligand. Whereas a sterically less demanding phosphine affords diphenylamine as the major product, it was shown that the amination reaction can be stopped after the first amination to give aniline if a sterically more encumbering phosphine ligand is used. Density functional theory calculations were carried out to examine the relationship between the steric demand of the phosphine ligand and the

SUBMITTER: Kim ST 

PROVIDER: S-EPMC8145866 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature