Comprehensive Evaluation of the Toxicity and Biosafety of Plasma Polymerized Nanoparticles.

ABSTRACT: The rapid growth of nanoparticle-based therapeutics has underpinned significant developments in nanomedicine, which aim to overcome the limitations imposed by conventional therapies. Establishing the safety of new nanoparticle formulations is the first important step on the pathway to clinical translation. We have recently shown that plasma-polymerized nanoparticles (PPNs) are highly efficient nanocarriers and a viable, cost-effective alternative to conventional chemically synthesized nanoparticles. Here, we present the first comprehensive toxicity and biosafety study of PPNs using both established in vitro cell models and in vivo models. Overall, we show that PPNs were extremely well tolerated by all the cell types tested, significantly outperforming commercially available lipid-based nan

SUBMITTER: Michael PL 

PROVIDER: S-EPMC8145910 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature