Ontology highlight
ABSTRACT:
SUBMITTER: Panebianco C
PROVIDER: S-EPMC8146031 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Panebianco Concetta C Trivieri Nadia N Villani Annacandida A Terracciano Fulvia F Latiano Tiziana Pia TP Potenza Adele A Perri Francesco F Binda Elena E Pazienza Valerio V
Biomolecules 20210426 5
Chemoresistance is a major problem in the therapeutic management of pancreatic cancer, concurring to poor clinical outcome. A number of mechanisms have been proposed to explain resistance to gemcitabine, a standard of care for this malignancy, among which is included aberrant miRNA expression. In the current study, we investigated the role of miR-217, which is strongly down-regulated in cancerous, compared to normal, pancreatic tissues or cells, in sensitizing human pancreatic cancer cell lines ...[more]