Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder.

ABSTRACT:

Background

Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrated positive clinical effects on behavior in young men and changes in urinary metabolomics in children with ASD.

Methods

We conducted a 15-week randomized parallel double-blind placebo-controlled clinical trial with 15-week open-label treatment and 6-week no-treatment extensions in 57 children, ages 3-12 years, with ASD over 36 weeks. Twenty-eight were assigned SF and 29 received placebo (PL). Clinical effects, safety and tolerability of SF were measured as were biomarkers to elucidate mechanisms of action of SF in ASD.

Results

Data

SUBMITTER: Zimmerman AW 

PROVIDER: S-EPMC8146218 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature