Extracellular Vesicle Release Promotes Viral Replication during Persistent HCV Infection.

ABSTRACT: Hepatitis C virus (HCV) infection promotes autophagic degradation of viral replicative intermediates for sustaining replication and spread. The excessive activation of autophagy can induce cell death and terminate infection without proper regulation. A prior publication from this laboratory showed that an adaptive cellular response to HCV microbial stress inhibits autophagy through beclin 1 degradation. The mechanisms of how secretory and degradative autophagy are regulated during persistent HCV infection is unknown. This study was performed to understand the mechanisms of viral persistence in the absence of degradative autophagy, which is essential for virus survival. Using HCV infection of a CD63-green fluorescence protein (CD63-GFP), labeled stable transfected Huh-7.5 cell, we found tha

SUBMITTER: Aydin Y 

PROVIDER: S-EPMC8146326 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature