NIR nanoprobe-facilitated cross-referencing manifestation of local disease biology for dynamic therapeutic response assessment.

ABSTRACT: Pharmacological interventions for effective treatment require opportune, dynamic and accurate manifestation of pathological status. Traditional clinical techniques relying on biopsy-based histological examinations and blood tests are dramatically restricted due to their invasiveness, unsatisfactory precision, non-real-time reporting and risk of complications. Although current strategies through molecular imaging enable non-invasive and spatiotemporal mapping of pathological changes in intact organisms, environment-activatable, sensitive and quantitative sensing platforms, especially for dynamic feedback of the therapeutic response, are still urgently desired in practice. Herein, we innovatively integrate deep-tissue penetrable multispectral optoacoustic tomography (MSOT) and near-infrared

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8146619 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature