Gene expression-based immune infiltration analyses of renal cancer and their associations with survival outcome.

ABSTRACT:

Background

Renal cancer is a common malignant tumor with an increasing incidence rate.

Methods

In this study, based on the gene expression profiles, we analyzed the compositions of tumor-infiltrating immune cells (TIICs) in renal cancer and paracancerous samples using CIBERSORT. The proportions of 22 TIICs subsets in 122 paired renal carcinoma and paracancerous samples, and 224 Wilms tumor (WT) samples varied between intragroup and intergroup.

Results

After analyzed the difference of TIICs composition between renal cancer and paired paracancerous samples, we found that M0 macrophages and CD8 T cells were significantly elevated, while naive B cells were significantly decreased in renal cancer samples compared with paracancerous samples. Survival analysis showed that hi

SUBMITTER: Chen L 

PROVIDER: S-EPMC8146654 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature