Genome-wide association analysis reveals that EDNRB2 causes a dose-dependent loss of pigmentation in ducks.

ABSTRACT:

Background

Birds have various plumage color patterns, and spot is a common phenotype. Herein, we conducted genome-wide association studies (GWAS) in a population of 225 ducks with different sized black spots to reveal the genetic basis of this phenomenon.

Results

First, we quantified the black spot phenotype within the duck population. The results showed that the uncolored area of the body surface first appeared on the ventral side. With increasing duck age, the area of the black spots was highly conserved across the whole body surface. The GWAS results identified a 198 kb (Chr4: 10,149,651 bp to 10,348,068 bp) genetic region that was significantly associated with the black spot phenotype. The conditional GWAS and linkage disequilibrium (LD) analysis further narrowed the ult

SUBMITTER: Xi Y 

PROVIDER: S-EPMC8146663 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature