The divergence of alternative splicing between ohnologs in teleost fishes.

ABSTRACT:

Background

Gene duplication and alternative splicing (AS) are two distinct mechanisms generating new materials for genetic innovations. The evolutionary link between gene duplication and AS is still controversial, due to utilizing duplicates from inconsistent ages of duplication events in earlier studies. With the aid of RNA-seq data, we explored evolutionary scenario of AS divergence between duplicates with ohnologs that resulted from the teleost genome duplication event in zebrafish, medaka, and stickleback.

Results

Ohnologs in zebrafish have fewer AS forms compared to their singleton orthologs, supporting the function-sharing model of AS divergence between duplicates. Ohnologs in stickleback have more AS forms compared to their singleton orthologs, which supports the acce

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8146666 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature