Metabolite Biomarkers of Leishmania Antimony Resistance.

ABSTRACT: Leishmania parasites cause leishmaniasis, one of the most epidemiologically important neglected tropical diseases. Leishmania exhibits a high ability of developing drug resistance, and drug resistance is one of the main threats to public health, as it is associated with increased incidence, mortality, and healthcare costs. The antimonial drug is the main historically implemented drug for leishmaniasis. Nevertheless, even though antimony resistance has been widely documented, the mechanisms involved are not completely understood. In this study, we aimed to identify potential metabolite biomarkers of antimony resistance that could improve leishmaniasis treatment. Here, using L. tropica promastigotes as the biological model, we showed that the level of response to antimony can be potentially

SUBMITTER: Gutierrez Guarnizo SA 

PROVIDER: S-EPMC8146733 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature