Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse.

ABSTRACT: Genomic imprinting, an epigenetic phenomenon that causes the expression of a small set of genes in a parent-of-origin-specific manner, is thought to have co-evolved with placentation. Many imprinted genes are expressed in the placenta, where they play diverse roles related to development and nutrient supply function. However, only a small number of imprinted genes have been functionally tested for a role in nutrient transfer capacity in relation to the structural characteristics of the exchange labyrinthine zone. Here, we examine the transfer capacity in a mouse model deficient for the maternally expressed Phlda2 gene, which results in placental overgrowth and a transient reduction in fetal growth. Using stereology, we show that the morphology of the labyrinthine zone in Phlda2-/+ mutants

SUBMITTER: Angiolini E 

PROVIDER: S-EPMC8146920 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature