Linking COVID-19 and Heme-Driven Pathophysiologies: A Combined Computational-Experimental Approach.

ABSTRACT: The SARS-CoV-2 outbreak was declared a worldwide pandemic in 2020. Infection triggers the respiratory tract disease COVID-19, which is accompanied by serious changes in clinical biomarkers such as hemoglobin and interleukins. The same parameters are altered during hemolysis, which is characterized by an increase in labile heme. We present two computational-experimental approaches aimed at analyzing a potential link between heme-related and COVID-19 pathophysiologies. Herein, we performed a detailed analysis of the common pathways induced by heme and SARS-CoV-2 by superimposition of knowledge graphs covering heme biology and COVID-19 pathophysiology. Focus was laid on inflammatory pathways and distinct biomarkers as the linking elements. In a second approach, four COVID-19-related proteins,

SUBMITTER: Hopp MT 

PROVIDER: S-EPMC8147026 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature