Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract. It is well established that the gut microbiome has a profound impact on IBD pathogenesis. Our aim was to systematically review the literature on the IBD gut microbiome and its usefulness to provide microbiome-based biomarkers. A systematic search of the online bibliographic database PubMed from inception to August 2020 with screening in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted. One-hundred and forty-four papers were eligible for inclusion. There was a wide heterogeneity in microbiome analysis methods or experimental design. The IBD intestinal microbiome was generally characterized by reduced species

SUBMITTER: Aldars-Garcia L 

PROVIDER: S-EPMC8147118 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature