Three-Finger Toxins from Brazilian Coral Snakes: From Molecular Framework to Insights in Biological Function.

ABSTRACT: Studies on 3FTxs around the world are showing the amazing diversity in these proteins both in structure and function. In Brazil, we have not realized the broad variety of their amino acid sequences and probable diversified structures and targets. In this context, this work aims to conduct an in silico systematic study on available 3FTxs found in Micrurus species from Brazil. We elaborated a specific guideline for this toxin family. First, we grouped them according to their structural homologue predicted by HHPred server and further curated manually. For each group, we selected one sequence and constructed a representative structural model. By looking at conserved features and comparing with the information available in the literature for this toxin family, we managed to point to potential

SUBMITTER: Kleiz-Ferreira JM 

PROVIDER: S-EPMC8147190 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature