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Endothelial and Vascular Health: A Tale of Honey, H2O2 and Calcium.


ABSTRACT: Intracellular Ca2+ regulation plays a pivotal role in endothelial biology as well as during endothelial restoration processes. Interest in honey utilization in wound approaches is rising in recent years. In order to evaluate the positive effects of buckwheat honey on endothelial responses, we utilized an immortalized endothelial cell line to evaluate cellular responses upon honey exposure, with particular interest in Ca2+ signaling involvement. The results highlight the positive effects of buckwheat honey on endothelial cells' responses and the central role played by Ca2+ signaling as an encouraging target for more efficacious clinical treatments.

SUBMITTER: Ranzato E 

PROVIDER: S-EPMC8147193 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Endothelial and Vascular Health: A Tale of Honey, H<sub>2</sub>O<sub>2</sub> and Calcium.

Ranzato Elia E   Bonsignore Gregorio G   Patrone Mauro M   Martinotti Simona S  

Cells 20210430 5


Intracellular Ca<sup>2+</sup> regulation plays a pivotal role in endothelial biology as well as during endothelial restoration processes. Interest in honey utilization in wound approaches is rising in recent years. In order to evaluate the positive effects of buckwheat honey on endothelial responses, we utilized an immortalized endothelial cell line to evaluate cellular responses upon honey exposure, with particular interest in Ca<sup>2+</sup> signaling involvement. The results highlight the pos  ...[more]

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