Transcriptomic and metabolomic characterization of post-hatch metabolic reprogramming during hepatic development in the chicken.

ABSTRACT:

Background

Artificial selection of modern meat-producing chickens (broilers) for production characteristics has led to dramatic changes in phenotype, yet the impact of this selection on metabolic and molecular mechanisms is poorly understood. The first 3 weeks post-hatch represent a critical period of adjustment, during which the yolk lipid is depleted and the bird transitions to reliance on a carbohydrate-rich diet. As the liver is the major organ involved in macronutrient metabolism and nutrient allocatytion, a combined transcriptomics and metabolomics approach has been used to evaluate hepatic metabolic reprogramming between Day 4 (D4) and Day 20 (D20) post-hatch.

Results

Many transcripts and metabolites involved in metabolic pathways differed in their abundance between D

SUBMITTER: Van Every HA 

PROVIDER: S-EPMC8147372 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature