Single-cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment.

ABSTRACT:

Background

The anti-tumor activity of anti-PD-1/PD-L1 therapies correlates with T cell infiltration in tumors. Thus, a major goal in oncology is to find strategies that enhance T cell infiltration and efficacy of anti-PD-1/PD-L1 therapy. TGF-β has been shown to contribute to T cell exclusion, and anti-TGF-β improves anti-PD-L1 efficacy in vivo. However, TGF-β inhibition has frequently been shown to induce toxicity in the clinic, and the clinical efficacy of combination PD-L1 and TGF-β blockade has not yet been proven. To identify strategies to overcome resistance to PD-L1 blockade, the transcriptional programs associated with PD-L1 and/or TGF-β blockade in the tumor microenvironment should be further elucidated.

Results

We used single-cell RNA sequencing in a mouse model to

SUBMITTER: Lim YW 

PROVIDER: S-EPMC8147417 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature