Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma.

ABSTRACT:

Background

Gliomas account for the majority of fatal primary brain tumors, and there is much room for research in the underlying pathogenesis, the multistep progression of glioma, and how to improve survival. In our study, we aimed to identify potential biomarkers or therapeutic targets of glioma and study the mechanism underlying the tumor progression.

Methods

We downloaded the microarray datasets (GSE43378 and GSE7696) from the Gene Expression Omnibus (GEO) database. Then, we used weighted gene co-expression network analysis (WGCNA) to screen potential biomarkers or therapeutic targets related to the tumor progression. ESTIMATE (Estimation of STromal and Immune cells in MAlignant Tumors using Expression data) algorithm and TIMER (Tumor Immune Estimation Resource) database

SUBMITTER: Yin W 

PROVIDER: S-EPMC8147444 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature