MicroRNAs miR-4535 and miR-1915-5p in amniotic fluid as predictive biomarkers for chorioamnionitis.

ABSTRACT:

Background

This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis.

Materials & methods

Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc's criteria.

Results

The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation.

Conclusion

miR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnio

SUBMITTER: Kiyoshima C 

PROVIDER: S-EPMC8147753 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature