Basophils as a potential marker of lupus nephritis by flow cytometry.

ABSTRACT:

Objective

To establish a convenient and simple flow cytometry immunophenotyping panel to explore immune cellular alterations and potential cellular biomarkers in systemic lupus erythematosus.

Materials and methods

This is a cross-sectional, case-control study including 60 patients with systemic lupus erythematosus and 20 sex- and age-matched healthy controls. A 14-color immunophenotyping panel was applied to detect proportions of circulating immune mononuclear cells, and comparisons between patients and healthy controls, and subgroups of patients, were performed. Correlations between cellular proportions and other parameters were investigated.

Results

After multivariate analysis, significantly decreased proportions of CD4^-CD8^- T cells, natural ki

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8147755 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature