Strategies for the Improvement of Metal-Based Chemotherapeutic Treatments.

ABSTRACT: This article provides an overview of the various research approaches we have explored in recent years to improve metal-based agents for cancer or infection treatments. Although cisplatin, carboplatin, and oxaliplatin remain the cornerstones in tumor chemotherapy, the discovery and approval of novel inorganic anticancer drugs is a very slow process. Analogously, although a few promising inorganic drugs have found clinical application against parasitic or bacterial infections, their use remains relatively limited. Moreover, the discovery process is often affected by small therapeutic enhancements that are not attractive for the pharmaceutical industry. However, the availability of increasing mechanistic information for the modes of action of established inorganic drugs is fueling the explora

SUBMITTER: Cirri D 

PROVIDER: S-EPMC8147839 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature