Pathophysiology and Treatment Options for Hepatic Fibrosis: Can It Be Completely Cured?

ABSTRACT: Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells, activation of different immune cells and signaling pathways, as well as a release of several inflammatory mediators take place, resulting in inflammation. Excessive inflammation drives hepatic stellate cell (HSC) activation, which then encounters various morphological and functional changes before transforming into proliferative and extracellular matrix (ECM)-producing myofibroblasts. Finally, enormous ECM accumulation interferes with hepatic function and leads to liver failure. To overcome this condition, several therapeutic approaches have been developed to inhibit inflammatory responses, HSC proliferation and activa

SUBMITTER: Khanam A 

PROVIDER: S-EPMC8147843 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature