Diabetic Complications and Oxidative Stress: A 20-Year Voyage Back in Time and Back to the Future.

ABSTRACT: Twenty years have passed since Brownlee and colleagues proposed a single unifying mechanism for diabetic complications, introducing a turning point in this field of research. For the first time, reactive oxygen species (ROS) were identified as the causal link between hyperglycemia and four seemingly independent pathways that are involved in the pathogenesis of diabetes-associated vascular disease. Before and after this milestone in diabetes research, hundreds of articles describe a role for ROS, but the failure of clinical trials to demonstrate antioxidant benefits and some recent experimental studies showing that ROS are dispensable for the pathogenesis of diabetic complications call for time to reflect. This twenty-year journey focuses on the most relevant literature regarding the main s

SUBMITTER: Iacobini C 

PROVIDER: S-EPMC8147954 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature