Dataset Information

CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.

ABSTRACT: In this work, we describe the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment. CRIMSON provides a powerful, customizable and user-friendly system for performing three-dimensional and reduced-order computational haemodynamics studies via a pipeline which involves: 1) segmenting vascular structures from medical images; 2) constructing analytic arterial and venous geometric models; 3) performing finite element mesh generation; 4) designing, and 5) applying boundary conditions; 6) running incompressible Navier-Stokes simulations of blood flow with fluid-structure interaction capabilities; and 7) post-processing and visualizing the results, including velocity, pressure and wall shear stress fields. A key aim of CRIMSON is to create a software environment that makes powerful computational haemodynamics tools accessible to a wide audience, including clinicians and students, both within our research laboratories and throughout the community. The overall philosophy is to leverage best-in-class open source standards for medical image processing, parallel flow computation, geometric solid modelling, data assimilation, and mesh generation. It is actively used by researchers in Europe, North and South America, Asia, and Australia. It has been applied to numerous clinical problems; we illustrate applications of CRIMSON to real-world problems using examples ranging from pre-operative surgical planning to medical device design optimization.

SUBMITTER: Arthurs CJ

PROVIDER: S-EPMC8148362 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.

Arthurs Christopher J CJ Khlebnikov Rostislav R Melville Alex A Marčan Marija M Gomez Alberto A Dillon-Murphy Desmond D Cuomo Federica F Silva Vieira Miguel M Schollenberger Jonas J Lynch Sabrina R SR Tossas-Betancourt Christopher C Iyer Kritika K Hopper Sara S Livingston Elizabeth E Youssefi Pouya P Noorani Alia A Ben Ahmed Sabrina S Nauta Foeke J H FJH van Bakel Theodorus M J TMJ Ahmed Yunus Y van Bakel Petrus A J PAJ Mynard Jonathan J Di Achille Paolo P Gharahi Hamid H Lau Kevin D KD Filonova Vasilina V Aguirre Miquel M Nama Nitesh N Xiao Nan N Baek Seungik S Garikipati Krishna K Sahni Onkar O Nordsletten David D Figueroa C Alberto CA

PLoS computational biology 20210510 5

In this work, we describe the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment. CRIMSON provides a powerful, customizable and user-friendly system for performing three-dimensional and reduced-order computational haemodynamics studies via a pipeline which involves: 1) segmenting vascular structures from medical images; 2) constructing analytic arterial and venous geometric models; 3) performing finite element mesh generation; 4) designing, and 5) applying boundary ...[more]

PMID: 33970900

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Dataset Information

CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.

Publications

CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.

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