Blood DNA methylation and COVID-19 outcomes.

ABSTRACT:

Background

There are no prior reports that compare differentially methylated regions of DNA in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 pandemic using a shared epigenotyping platform. We performed a genome-wide analysis of circulating blood DNA CpG methylation using the Infinium Human MethylationEPIC BeadChip on 124 blood samples from hospitalized COVID-19-positive and COVID-19-negative patients and compared these data with previously reported data from 39 healthy individuals collected before the pandemic. Prospective outcome measures such as COVID-19-GRAM risk-score and mortality were combined with methylation data.

Results

Global mean methylation levels did not differ between COVID-19 patients and healthy pre-pandemic controls. About

SUBMITTER: Balnis J 

PROVIDER: S-EPMC8148415 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature