Kinetics of anti-SARS-CoV-2 antibodies over time. Results of 10 month follow up in over 300 seropositive Health Care Workers.

ABSTRACT:

Background

The kinetics of the antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) needs to be evaluated since long-term duration of antibody remains largely unknown, particularly in infected healthcare workers (HCW).

Methods

Prospective study, evaluating the longitudinal profile of anti-SARS-CoV-2 antibody titers in a random sample of 331 seropositive healthcare workers (HCW) of Spanish Hospitals Group. Serial measurements of serum IgG-anti-SARS-CoV-2 were obtained at baseline (April-May,2020), and in 2 follow-up visits. Linear mixed models were used to investigate antibody kinetics and associated factors.

Results

A total of 306 seropositive subjects (median age: 44.7years;69.9% female) were included in the final analysis. After a median f

SUBMITTER: Varona JF 

PROVIDER: S-EPMC8148432 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature