Identification of potential autophagy-associated lncRNA in prostate cancer.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) have been linked to autophagy. It is urgent to identify and assess the hub autophagy-associated lncRNA in prostate cancer.

Methods

Differentially expressed lncRNAs associated with autophagy were identified in prostate cancer based on The Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) data. An autophagy-mediated competing endogenous RNA network was constructed to screen for autophagy-associated lncRNA, and the preselected lncRNAs were further validated using Gene Expression Omnibus (GEO) datasets. Furthermore, a prognostic lncRNA signature was established and assessed. Additionally, Gene Set Enrichment Analysis (GSEA) revealed the underlying molecular mechanisms.

Results

Using a competing endogenous RNA network, 66 dif

SUBMITTER: Li J 

PROVIDER: S-EPMC8148478 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature