Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection.

ABSTRACT: Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody responses in the same patients. Antibody responses as well as T and B cell activation differentiate primary from secondary responses. Hospitalization is associated with lower frequencies of activated, terminally differentiated T cells and higher percentages of effector memory CD4 T cells. Patients with more severe disease tend to have higher percentages of plasmablasts. This does not translate into long-term antibody titers, since neutralizing titers after 6 months correlate with percentages of specific memory B cells, but not with acute plasmablast ac

SUBMITTER: Rouers A 

PROVIDER: S-EPMC8149372 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature