Occupational exposure to antimony trioxide: a risk assessment.

ABSTRACT:

Objectives

The US National Toxicology Program (NTP) recently recommended in its Report on Carcinogens Monograph for Antimony Trioxide that antimony trioxide be listed as 'reasonably anticipated to be a human carcinogen' based on sufficient evidence of carcinogenicity in experimental animals and supporting evidence from mechanistic studies. Our goal was to estimate the possible human cancer risk from occupational exposure to antimony trioxide.

Methods

We selected data from 2-year inhalation studies in male and female mice conducted by the NTP and performed cancer dose-response analyses using cancer models and benchmark dose methods developed by the US Environmental Protection Agency. In these analyses, we generated benchmark doses and cancer slope factors for antimony

SUBMITTER: Schildroth S 

PROVIDER: S-EPMC8149478 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature