Association of quantitative CT lung density measurements and lung function decline in World Trade Center workers.

ABSTRACT:

Background

Occupational exposures at the WTC site after 11 September 2001 have been associated with presumably inflammatory chronic lower airway diseases.

Aims

In this study, we describe the trajectories of expiratory air flow decline, identify subgroups with adverse progression, and investigate the association of those trajectories with quantitative computed tomography (QCT) imaging measurement of increased and decreased lung density.

Methods

We examined the trajectories of expiratory air flow decline in a group of 1,321 former WTC workers and volunteers with at least three periodic spirometries, and using QCT-measured low (LAV%, -950 HU) and high (HAV%, from -600 to -250 HU) attenuation volume percent. We calculated the individual regression line slopes for first-se

SUBMITTER: Liu X 

PROVIDER: S-EPMC8149480 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature